Insulin resistance in cats can manifest when blood glucose levels remain high despite increasing insulin doses. This issue might arise from improper insulin administration, dietary inconsistencies, or underlying medical conditions.

Step 1: Review Basics

• Proper Insulin Administration: Ensure correct dosing and injection technique. Use the appropriate syringe and store insulin correctly.
• Dietary Control: Consistent feeding schedules and diabetic-friendly diets are crucial. Avoid high-carb treats and ensure no unapproved snacks are given.

Step 2: Diagnose Insulin Resistance

A glucose curve test can help determine if insulin is not being properly absorbed or if there’s a Somogyi effect, where an overly high insulin dose leads to hypoglycemia followed by rebound hyperglycemia.

Step 3: Check for Medications and Illnesses

Certain medications, like corticosteroids, can elevate blood sugar levels. Additionally, unspayed female cats or those with infections or other diseases may experience insulin resistance. Screening for conditions like hyperthyroidism and Cushing’s disease is essential.

Step 4: Explore Rare Conditions

Conditions like acromegaly or insulin antibodies might be contributing to insulin resistance. Diagnostic imaging or blood tests can help identify these issues.